| 名稱 | hClaudin18.2/MC38 |
| 型號(hào) | CBPG0017 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | hClaudin18.2/MC38 |
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Email： zhangxiangwen@cobioer.com
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBPG0017hClaudin18.2/MC38
- 詳細(xì)內(nèi)容
| I. Background | |||
Claudin18是位于細(xì)胞膜表面緊密連接的主要成分，它在維持細(xì)胞極性和屏障功能以及促進(jìn)耐酸能力方面起著重要作用。CLDN18的第一個(gè)外顯子可以選擇性剪接，形成兩個(gè)具有高度同源氨基酸序列的不同剪接突變體(CLDN18.1和CLDN18.2)。跨膜蛋白CLDN18由兩個(gè)細(xì)胞外環(huán)、四個(gè)跨膜結(jié)構(gòu)域和一個(gè)細(xì)胞質(zhì)結(jié)構(gòu)域組成。 | |||
| II. Introduction | |||
| Host Cell: | MC-38 | ||
| Expressed gene: | Claudin18.2 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | DMEM+10%FBS+2μg/ml Puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mus musculus, mouse | ||
| Tissue: | Colon | ||
| Morphology: | Epitheloid cell | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |
Figure 1. Recombinant hClaudin18.2/MC-38 stably expressing Claudin18.2. | |
| V. In VIVO Data | |
Index | Content |
Animal | C57BL/6J, 7weeks, female |
Implanted Position | Subcutaneous (right lower flank region ) |
Injected Cell Numbers | 1×10^6/0.1ml |
Matrix gel | Without matrix gel |
1. Weight Change
Figure 2. hClaudin18.2/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3. hClaudin18.2/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
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